Programma MD-PhD della Scuola di Medicina

Study of the potentialities of adult stem cells in regenerative medicine. Identification of gene(s) involved in stemness maintenance. Responsabile prof Fiorella Altruda

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Programma

One of the current research interests is to explore the potentiality of spermatogonial stem cells as a novel tool for cell therapy, with particular emphasis on liver metabolic diseases. Spermatogonial stem cells have been isolated from mice and are currently in culture in the laboratory. These stem cells have been found to convert spontaneously to pluripotent stem cells, termed germ cell-derived pluripotent stem cells or GPSCs. However, very little is known about the factors responsible for the conversion of spermatogonial stem cells to pluripotent stem cells. The Unit has developed a system for differentiating GPSCs into hepatocyte-like cells and renal cells and research on this aspects is presently under way. The main aims are to:-Develop culture conditions and identify factors responsible to differentiate GPSCs into hepatocytes as well as renal cells.- identify genes that are enhancers of reprogramming.

Attività di supporto

Collaboratori: Sharmila Fagoonee, Letizia De Chiara

Note

• Progetto del Corso Cellule staminali e medicina rigenerativa
• Qualificazione scientifica: Pubblicazioni su PubMed
• Struttura in cui si svolge attività di ricerca: Laboratorio di Genetica Molecolare del Molecular Biotechnology Center, Via Nizza 52, 10126 Torino

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