Vai al contenuto principale
Coronavirus: aggiornamenti per la comunità universitaria / Coronavirus: updates for UniTo Community
Oggetto:

Understanding the functions of primary microcephaly genes and exploring their potential as therapeutic targets in brain tumors. Instructor prof Ferdinando Di Cunto

Docente
Prof. Ferdinando Di Cunto (Coordinatore)
Corso di studio
Programma MD-PhD della Scuola di Medicina
Tipologia
teorico-pratico
Erogazione
Frequenza di laboratori e/o reparti
Lingua
Italiano/Inglese
Frequenza
Obbligatoria
Tipologia esame
Prova pratica
Oggetto:

Sommario insegnamento

Oggetto:

Programma

The development of human brain, in particular of cerebral cortex, is characterized by intense proliferation of undifferentiated neural progenitors, followed by permanent exit from cell cycle and by a complex differentiation program, leading to wiring of an astonishing neural network. Any alteration of these processes can have severe anatomical and functional consequences, such as brain volume reduction (microcephaly), intellectual disability, movement disorders, epilepsy and cancer. Genetic primary microcephaly (MCPH) is a rare recessive disorder in which the proliferative expansion of neural progenitors is specifically compromised. Considering the molecular similarities between neural stem cells and cancer stem cells that maintain brain tumors, MCPH genes are attractive potential targets for counteracting these aggressive cancers. Using in vitro and in vivo models, our group studies the molecular mechanisms by which mutation of MCPH genes leads to microcephaly. In addition, we investigate the anti-neoplastic effects of functionally inactivating these genes in brain tumor cells.

The objective of the internship will be to provide a strong theoretical and practical basis for the experimental analysis of MCPH genes, both during normal development and in brain tumor cells.

Oggetto:

Attività di supporto

Co-workers Dr. Gaia Berto and Dr. Gianmarco Pallavicini

Testi consigliati e bibliografia



Oggetto:

Note

Registrazione
  • Aperta
    Apertura registrazione
    01/03/2020 alle ore 00:00
    Chiusura registrazione
    31/12/2022 alle ore 23:55
    Oggetto:
    Ultimo aggiornamento: 24/10/2019 15:09