Programma MD-PhD della Scuola di Medicina

Electrophysiological and molecular mechanisms of spino-cerebellar ataxias. Instructor prof Filippo Tempia

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Programma

Spinocerebellar ataxias (SCAs) include more than 40 different types of diseases of the central nervous system. The incidence of SCAs is 1 every 30,000 subects and at present there is no cure. Our laboratory is studying animal models of SCA27 and SCA38. The latter is caused by mutations of the gene ELOVL5. The aim of our study is to understand the pathogenic mechanism and its connections to new physiological roles of Elovl5. The experimental techniques used for this study are: i) motor tests to follow up the evolution of the disease in the animal models; ii) immunohistochemistry in brain sections of the animal models; iii) electrophysiological recordings of membrane potential and ionic currents by the patch-clamp tecnique in brain slices from animal models; gene expression by quantitative RT-PCR. Our studies are aimed at aquiring knowledge necessary to design new therapeutic approaches. A second line of research regards the role of cerebellum in autism, studied in animal models with genetic modifications frequently found in patients. Finally, we study the mechanisms underlying the control of anxiety and depression by a novel subunit of voltage-dependent sodium channels.

Attività di supporto

Co-workers:Dr. Eriola Hoxha, Dr. Ilaria Balbo

Note

• Progetto del Corso: Basi molecolari e cellulari della patologia, morte e rigenerazione delle cellule nervose
• Scientific qualification of the PI: Entrez-PubMed Link to publications of Prof Tempia

• Laboratory: Neurophysiology of neurodegenerative diseases, Neuroscience Institute Cavalieri Ottolenghi (NICO), inside the San Luigi Gonzaga Hospital at Orbassano.

  Department: Dept. of Neuroscience

  Address: Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonazole 10, 10043 Orbassano (TO).

  Contacts: Prof. Filippo Tempia - e-mail: filippo.tempia@unito.it - tel: 011-6706609.

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